Some novel derivatives of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-1,3-thiazinan-4-one were synthesized and characterized by their MOISTURE CURE 2-PHASE physical and spectral data.All the synthesized compounds were subsequently screened for in vitro antimalarial activity against chloroquine sensitive strain of Plasmodium falciparum (RKL-2) employing chloroquine as the reference drug.Most of the synthesized compounds exhibited mild to moderate susceptibilities towards the parasite in comparison to the standard.
It was found that antimalarial activity of 3-(3-(7-chloroquinolin-4-ylamino)propyl)-2-(4-bromophenyl)-1,3-thiazinan-4-one Financing was marginally superior than all the compounds evaluated.